28th National Clinical Education Symposium Presentation Abstracts

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OP-60 Cardiac Electrophysiological Changes in Patients with Methamphetamine and Cannabis Use Disorder: A Comparative ECG Study - Page 148
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OP-61 Psychological Resilience and Suicidality in Bipolar Disorder: Exploring the Impact of Metabolic Syndrome - Page 150
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OP-62 The Relationship Between Sleep Quality, Chronotype, and Resilience and Suicide Risk in Major Depression - Page 152
Amine Kilictutan, Simge Seren Kirlioglu Balcioglu

OP-63 Investigation Of The Association Of Leptin (LEP) ?2548g/A (Rs7799039) and Leptin Receptor (LEPR) 668a/G (Rs1137101) Gene Polymorphisms With Clinical Parameters And Disorder Subtypes In Individuals With Panic Disorder - Page 153
Nisa Nur Yıldırım, Hasan Mervan Aytaç, Sacide Pehlivan, Fatıma Ceren Tunçel

OP-65 Comparison of the Readability Levels of Package Inserts of Commonly Used Antidepressant and Antipsychotic Medications in Turkey - Page 155
Duçem Selena İşmar, Gamze Burhan, Güneş Devrim Kıcalı

OP-66 Effects of Electroconvulsive Therapy on Hemogram-Derived Inflammatory Indices in Bipolar Mania: A Case–Control Study - Page 157
İrem Demiral, Sinay Önen, Emine Merve Akdağ

21 APRIL 2026, TUESDAY
08:45- 10:00 OP-59 Valproate Is Associated with Lower Inflammatory Burden in Euthymic Bipolar Disorder: Evidence from Novel Composite Inflammatory Indices

OP-59 Valproate Is Associated with Lower Inflammatory Burden in Euthymic Bipolar Disorder: Evidence from Novel Composite Inflammatory Indices

Betül Bakay1, Fatmanur Akgün Kılavuz2

1. Konya City Hospital, Department of Psychiatry, Konya, Türkiye
2. Necmettin Erbakan University, Faculty of Medicine, Department of Psychiatry, Konya, Türkiye

DOI: 10.5080/61upk.ozt475 Page 147

BACKGROUND AND AIM:Systemic inflammation is increasingly recognized as a core component of the pathophysiology and neuroprogression of bipolar disorder (BD). Novel composite hematologic indices, including the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune-inflammation value (PIV), offer accessible measures of the inflammatory burden. However, the effects of mood stabilizers on these parameters remain unclear. This study aimed to examine the association between lithium and/or valproate (VPA) treatment and systemic inflammatory burden in euthymic patients with BD.
METHODS (Ethics Committee Approval must be obtained and the number should be specified.):A total of 520 euthymic patients with DSM-5–diagnosed BD were included and classified into four groups: no lithium/VPA, VPA, lithium, and lithium+VPA. Sociodemographic and clinical variables, complete blood count parameters, and derived inflammatory indices (SII, SIRI, and PIV) were compared. This study was approved by the Ethics Committee of Necmettin Erbakan University (IRB: 2025/5925).
RESULTS:The groups were largely comparable in terms of sociodemographic features. The lithium+VPA group exhibited a more severe illness course, including longer disorder duration and higher episode and hospitalization counts (all p?.001). The VPA group demonstrated significantly lower neutrophil counts and reduced SII, SIRI, and PIV values than the lithium and no lithium/VPA groups (all p<.001). In the regression analysis, VPA use independently predicted lower SII levels (?=–0.168, p=.021), whereas lithium use showed no significant association (p=.481). Inflammatory indices were not correlated with illness duration, number of episodes, or hospitalization history.
CONCLUSIONS:Valproate treatment was associated with a reduced systemic inflammatory burden in euthymic BD, independent of clinical severity. In contrast, lithium was not associated with lower inflammatory indices. These findings suggest that VPA may exert an anti-inflammatory effect beyond mood stabilization, highlighting the relevance of immuno-inflammatory mechanisms in treatment selection and the long term course of BD. Keywords: Systemic inflammation, bipolar disorder, valproate