28th National Clinical Education Symposium Presentation Abstracts

Actions for Presentation

Download PDF Back to list

Other presentations

OP-61 Psychological Resilience and Suicidality in Bipolar Disorder: Exploring the Impact of Metabolic Syndrome - Page 150
Eylül Yeral, Filiz Kulacaoğlu Öztürk

OP-62 The Relationship Between Sleep Quality, Chronotype, and Resilience and Suicide Risk in Major Depression - Page 152
Amine Kilictutan, Simge Seren Kirlioglu Balcioglu

OP-63 Investigation Of The Association Of Leptin (LEP) ?2548g/A (Rs7799039) and Leptin Receptor (LEPR) 668a/G (Rs1137101) Gene Polymorphisms With Clinical Parameters And Disorder Subtypes In Individuals With Panic Disorder - Page 153
Nisa Nur Yıldırım, Hasan Mervan Aytaç, Sacide Pehlivan, Fatıma Ceren Tunçel

OP-65 Comparison of the Readability Levels of Package Inserts of Commonly Used Antidepressant and Antipsychotic Medications in Turkey - Page 155
Duçem Selena İşmar, Gamze Burhan, Güneş Devrim Kıcalı

OP-66 Effects of Electroconvulsive Therapy on Hemogram-Derived Inflammatory Indices in Bipolar Mania: A Case–Control Study - Page 157
İrem Demiral, Sinay Önen, Emine Merve Akdağ

OP-67 Sociotelism and psychiatric symptoms in medical faculty students - Page 159
fatma KARTALKırıkkale University Faculty of Medicine, Department of Psychiatry, Kırıkkale, Türkiye, Berk Arı ?ca, hatice polat

21 APRIL 2026, TUESDAY
08:45- 10:00 OP-60 Cardiac Electrophysiological Changes in Patients with Methamphetamine and Cannabis Use Disorder: A Comparative ECG Study

OP-60 Cardiac Electrophysiological Changes in Patients with Methamphetamine and Cannabis Use Disorder: A Comparative ECG Study

Emre Nedret Sezgin1, Filiz Kulacaoglu1, Merve Gumusay2

1. 1University of Health Sciences Bakirkoy Prof Dr Mazhar Osman Research and Training Hospital for Psychiatry, Neurology, and Neurosurgery, Department of Psychiatry, Istanbul, Türkiye
2. University of Health Sciences Haydarpasa Numune Research and Training Hospital, Department of Psychiatry, Istanbul, Türkiye

DOI: 10.5080/61upk.ozt476 Page 148

BACKGROUND AND AIM Methamphetamine exerts strong sympathomimetic and direct cardiotoxic effects, whereas the electrophysiological impact of cannabis remains less clearly defined. This study aimed to compare electrocardiographic markers of cardiac depolarization and repolarization among individuals with methamphetamine use disorder, cannabis use disorder, and healthy controls.
METHODS This cross-sectional study included 53 patients with methamphetamine use disorder, 54 with cannabis use disorder, and 51 healthy controls without substance use. The study was approved by the Institutional Ethics Committee (Approval No: 2023-15142 ). All participants underwent standard 12-lead electrocardiography. Analyzed parameters included corrected QT interval (QTc), QT dispersion (QTd), corrected JT interval (JTc), JT dispersion (JTd), Tp–e interval, Tp–e/QTc ratio, P-wave dispersion, frontal QRS axis, heart rate, PR interval, and fragmented QRS complexes (fQRS). Continuous variables were expressed as median (interquartile range) and analyzed using the Kruskal–Wallis test with Bonferroni-adjusted post hoc comparisons. Categorical variables were compared using chi-square or Fisher’s exact tests.
RESULTS Significant intergroup differences were observed in ventricular repolarization parameters. QTc values were significantly higher in the methamphetamine group compared with both cannabis users and controls (p = 0.004). QT dispersion was increased in methamphetamine users compared with controls (p = 0.006). JT dispersion showed the most pronounced difference, with significantly higher values in the methamphetamine group than in the other groups (p < 0.001). The prevalence of fragmented QRS complexes was also higher in methamphetamine users compared with controls (p = 0.032).
CONCLUSIONS Methamphetamine use is associated with prolonged QTc, increased QT dispersion, elevated JT dispersion, and a higher prevalence of fragmented QRS complexes, indicating increased arrhythmogenic potential. Cannabis use was not associated with significant electrocardiographic alterations compared with controls, although a trend toward greater repolarization heterogeneity was observed. Keywords Methamphetamine use disorder; Cannabis use disorder; Electrocardiography; Ventricular repolarization; QT interval; JT dispersion; Arrhythmia risk