28th National Clinical Education Symposium Presentation Abstracts

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OP-41 Extrapyramidal symptom severity across neuroanatomical subtypes of schizophrenia identified by machine learning - Page 120
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OP-43 Cognitive Subtyping in Schizophrenia: An Analysis of Neuropsychological Profiles, Clinical Symptomatology, and the Impact of Illness Duration using the COBRE Dataset - Page 123
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OP-44 State Anxiety and Uncertainty Processing: A Hierarchical Gaussian Filter Study in Generalized Anxiety Disorder - Page 125
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OP-45 The Effect of Shift Work on Emotion Regulation and Life Satisfaction in Healthcare Workers - Page 126
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OP-46 Emotional, Behavioral and Social Functioning in Children of Parents with Alcohol and Substance Use Disorders: A Case–Control Study - Page 127
Başak Güldür, Başak Bağcı, Aslı Tuğba Esen, Canem Kavurma, Ercan Durmaz

20 APRIL 2026, MONDAY
17:00 - 18:15 "OP-40 Lactose intolerance symptoms, irritable bowel syndrome and symptom severity in patients with major depressive and anxiety disorders under antidepressant treatment"

OP-40 Lactose intolerance symptoms, irritable bowel syndrome and symptom severity in patients with major depressive and anxiety disorders under antidepressant treatment

Habib Berhan Akyıldız1, Sinan Yetkin1

1. Psychiatry, Gulhane Training and Research Hospital, Ankara, Turkey

DOI: 10.5080/61upk.ozt457 Page 118

BACKGROUND AND AIM:There is increasing evidence for a bidirectional interaction between MDD, anxiety disorders and GI dysfunctions. This study aims to evaluate the prevalence of GI symptoms in patients with MDD and anxiety disorders using lactosecontaining antidepressants, the relationship between IBS symptoms and psychiatric symptom severity and the association of lactose intolerance symptoms with the lactose content of medications.
METHODS (Ethics Committee Approval must be obtained and the number should be specified.):This study was conducted using a hybrid design incorporating both crosssectional and prospective cohort methodologies. The sample consisted of 300 participants with MDD, anxiety disorders and healthy controls. Antidepressants were classified as lactose-containing or lactose-free based on excipient information obtained from official database of the TITCK. A subgroup of patients reporting lactose intolerance symptoms was re-evaluated after a 6–8 week lactose-free diet and continued antidepressant therapy. Patients reporting lactose intolerance symptoms received standardized information regarding lactose-containing foods. Those who did not adhere to recommendations and lactose intake during follow-up were excluded to minimize external lactose exposure as a confounding factor. It was approved by the Ethics Committee for Scientific Research of the University of Health Sciences Gulhane with decision no:2024-73 (14.11.2024).
RESULTS:Increased IBS severity was associated with HADS-Anxiety, HADS-Depression and SDQ-20, whereas SSAS scores did not differ significantly between IBS severity groups. Furthermore, patients using lactose-free antidepressants showed more prominent reductions in lactose intolerance symptoms particularly gas, bloating, nausea/vomiting and belching within 6–8 weeks compared to those using lactosecontaining medications. Multivariate logistic regression analysis identified age, HADSDepression, SSAS and SDQ-20 scores as independent risk factors for IBS.
CONCLUSIONS:Patients with IBS complaints exhibited increased psychiatric symptoms and heightened somatic sensitivity; age, depression scores, dissociative symptoms and somatic amplification were identified as important predictors of IBS. Although the lactose content of antidepressants is relatively low, heightened visceral sensitivity may render excipient exposure clinically significant. Keywords: Major depressive disorder, anxiety disorder, lactose intolerance, irritable bowel syndrome