28th National Clinical Education Symposium Presentation Abstracts

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OP-13 Retrospective Analysis of the Effect of Sociodemographic Factors and Disease Duration on Yale-Brown Scale Scores in Patients with Treatment-Resistant Obsessive-Compulsive Disorder Who Had Transcranial Magnetic Stimulation at the Psychiatry Clinic - Page 76
FERDANUR Yolcu Çiftlik, Pelin Göksel, Gökçe Çamoğlu

OP-14 Sexual Satisfaction, Guilt, and Shame in Women with Obsessive–Compulsive Disorder and Generalized Anxiety Disorder - Page 77
Selin Karakaya, , Ezgi Sıla Ahi Üstün, , Büşra Söylemez Karakuş, , Nurdan Özder, , İrem Tanrıkulu, , Meram Can Saka

OP-15 Factors Affecting Attitudes Toward Seeking Psychological Help, Self-Stigma, and Social Stigma Among University Students: A Cross-Sectional Analysis - Page 79
Muhammet Sancaktar, Bahadir Demir, Gülçin Elboga, Feridun Bülbül, Abdurrahman Altındağ

OP-16 Cognitive Factors Associated with Beliefs About Psychiatry Among Medical Interns: A Transdiagnostic Perspective - Page 81
Mehmet Eren Yaşaran, İlker Güneysu

OP-17 Clinical Efficacy of Electroconvulsive Therapy in Hospitalized Patients with Depressive Episode - Page 83
Pelin Göksel, Tuna Kaygusuz

OP-18 Construction and Analysis of a Pseudogene-centered RNA-RNA Interaction Network for GUSBP2 in Generalized Anxiety Disorder: A Bioinformatics Approach - Page 84
Manolya Ün, Kerem Laçiner

20 APRIL 2026, MONDAY
10:15 - 11:30 OP-12 Efficacy of rTMS Treatment in Treatment-Resistant Major Depressive Disorder: The Role of Sociodemographic Characteristics and Duration of Illness on Treatment Response

OP-12 Efficacy of rTMS Treatment in Treatment-Resistant Major Depressive Disorder: The Role of Sociodemographic Characteristics and Duration of Illness on Treatment Response

Erşad Yasin Yıldız1, Pelin Goksel1, Gökçe Çamoğlu1

1. Department of Psychiatry, Ondokuz Mayıs University, Samsun, Turkey

DOI: 10.5080/61upk.ozt431 Page 75

BACKGROUND AND AIM Major Depressive Disorder (MDD) is a chronic condition where full remission remains elusive for a significant portion of patients despite standard interventions. The objective of this study was to examine the efficacy of high-frequency Repetitive Transcranial Magnetic Stimulation (rTMS) applied to the left dorsolateral prefrontal cortex (DLPFC) on depressive symptoms in patients with treatment-resistant MDD, and to evaluate the impact of factors such as age, gender, and duration of illness on treatment response.
METHODS Approved by the Ondokuz Mayıs University Clinical Research Ethics Committee (Decision No: 2026/29), this retrospective study included 24 patients (18 female, 5 male; mean age: 47.65 ± 11.29 years) diagnosed with treatment-resistant MDD. Patients underwent 20 rTMS sessions (5 days/week for 4 weeks). Treatment efficacy was analyzed by comparing Hamilton Depression Rating Scale (HAM-D) scores assessed immediately before the first and after the final session. All patients received concurrent psychopharmacological treatment. However, due to the retrospective design and heterogeneity/missing data regarding medication usage, between-group comparisons based on dose equivalence were not performed.
RESULTS The mean pre-treatment HAM-D score was 15.62 ± 5.59, which significantly decreased to 7.75 ± 6.39 following rTMS treatment (p<0.001), representing a mean improvement of 7.87 points. No statistically significant relationship was found between treatment response and age (p=0.41), duration of illness (p=0.08), gender (p=0.87), or marital status (p=0.37).
CONCLUSIONS Our results confirm that high-frequency rTMS applied to the left DLPFC is highly effective in reducing symptom severity in treatment-resistant depression. Crucially, treatment response was not influenced by age, gender, or illness duration. This suggests that rTMS remains a robust therapeutic option even for chronic, longstanding cases, supporting its use across a diverse patient demographic Keywords: Major depressive disorder, Treatment-resistant depression, Repetitive transcranial magnetic stimulation (rTMS), Sociodemographic factors, Duration of illness, Treatment efficacy