28th National Clinical Education Symposium Presentation Abstracts

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OP-04 Comparison of the Heart-Brain Coupling Paradigm Between the Dorsomedial and Dorsolateral Prefrontal Cortices and Evaluation of Its Association with Response to Accelerated iTBS Treatment Targeting the Dorsomedial Prefrontal Cortex - Page 60
Ali Tarık Altunç, , Melike Nur Altunç, , Yusuf Çiçek, , Ahmet Torun, , Sarp Yoldas, , Burç Çağrı Poyraz

OP-05 Associations Between Suicide Attempt Severity and Routine Inflammatory and Hematological Markers - Page 62
Hale Rodriguez Camacho, Fatih Ekici

OP-06 Post-Traumatic Stress Disorder and Complex Post-Traumatic Stress Disorder in Fibromyalgia: A Pilot Study - Page 63
Cansu Ünsal Mavi, , Öznur Dilara Tüzün, , Rabia Bahar Demircan Endeş, , Asude Ak, , Meltem Karaatlı Erdoğan

OP-07 Association Between Smartphone Addiction and Attention Performance - Page 65
Taylan Tanışan, , Süheyla Ünal

OP-08 Metabolic Syndrome Shows an Independent Association with Comorbid Major Depressive Disorder in Schizophrenia Remission: A Cross-Sectional Study - Page 67
Mehmet Avan, , Hayriye Dilek Hamurcu, , Begüm Pekiyi Avan, , Ali Çayköylü

OP-09 The relationship between mental symptoms and body perception and selfesteem in patients wıth nasal septal deviatıon - Page 69
Ömer Naim Sayer, , Zeynep Soytürk, , Zerrin Ozergin Coskun, , Cicek Hocaoglu

20 APRIL 2026, MONDAY
08:45 - 10:00 "OP-03 Investigation of MAO-A Gene, miR-132-3p, and miR-330-3p Activity in Adolescents with Non-Suicidal Self-Injury"

OP-03 Investigation of MAO-A Gene, miR-132-3p, and miR-330-3p Activity in Adolescents with Non-Suicidal Self-Injury

Raziye ülkü kıcalı1, Nilfer Sahin1, Tuba Gökdoğan Edgünlü2

1. Department of Child and Adolescent Psychiatry, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Türkiye
2. Department of Medical Biology, Division of Basic Medical Sciences, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Türkiye

DOI: 10.5080/61upk.ozt422 Page 58

BACKGROUND AND AIM Non-suicidal self-injury (NSSI) is defined as deliberate and repetitive acts of direct bodily harm without suicidal intent. Previous studies implicate MAO-A and microRNAs in psychiatric disorders. The aim of this study was to investigate the relationship between NSSI and the monoamine oxidase A (MAO-A) gene, and the microRNAs miR132-3p and miR-330-3p, in adolescents diagnosed with NSSI.
METHODS The study included 42 adolescents aged 12–18 years with NSSI and 42 age- and sexmatched healthy controls. Ethics approval was obtained from the İzmir Bakırçay University Non-Interventional Clinical Research Ethics Committee (Decision No: 2249, 14.05.2025). To determine MAO-A gene, miR-132-3p and miR-330-3p expression levels, 5 mL of venous blood samples were collected from all participants. The miRNAs investigated in this study were selected based on data obtained from the miRDB database (https://mirdb.org/mirdb/index.html) and evidence from previous studies in the literature.
RESULTS The results demonstrated that MAO-A gene expression levels were significantly higher in the NSSI group compared to the control group, whereas miR-132-3p and miR-330-3p expression levels were significantly lower in the NSSI group. DISCUSSION The elevated MAO-A expression observed in adolescents with NSSI supports existing evidence implicating monoaminergic dysregulation in affective instability and impulsive behaviors. Previous studies have emphasized the interaction between MAOA-related vulnerability and environmental stressors in self-injurious behavior, and our findings extend this perspective at the expression level. The decreased levels of miR-132-3p and miR-330-3p suggest disrupted post-transcriptional regulation, consistent with literature linking these microRNAs to stress response, neuroplasticity, and mood-related psychopathology. Together, these findings support a biologically informed model of NSSI vulnerability.
CONCLUSIONS The findings highlight the importance of addressing NSSI as a multidimensional phenomenon and integrating biological markers into clinical assessments. Such integration may enhance risk prediction and support the development of personalized preventive and therapeutic strategies. Keywords: Adolescent, MAO-A, miR-132-3p, miR-330-3p, Non-suicidal self-injury