27th National Clinical Education Symposium Presentation Abstracts
29 APRIL 2025, MONDAY
13:00-14:00 POSTER PRESENTATION SESSION-2
Periorbital Oedema Induced by Sertraline
Leyla Çelik1, Şuheda Tapan Çelikkaleli1
-
Show more (Affiliations)
1. Van Yüzüncü Yıl University, Department of Psychiatry, Van
DOI: 10.5080/kes27.abs137 Page 163
OBJECTIVE:This case report presents periorbital oedema, a rare side effect of sertraline in a 60-year-old man. Although periorbital oedema is a known side effect of some drugs, it has not been commonly associated with sertraline. CASE (The patient consent must be provided and specified with appropriate terms.)::A 60-year-old man presented with complaints of emotional fluctuations, crying, ruminative thoughts, restlessness and insomnia in 2021. Initially, escitalopram 10 mg/day was started and increased to 20 mg/day due to inadequate response. However, since the patient could not tolerate this dose, treatment was changed to sertraline 50 mg/day. Due to inadequate response, sertraline dose was increased to 100 mg/day and depressive symptoms improved. After sertraline 50 mg/day was started, periorbital oedema developed in both eyes. The patient was referred to related specialities but no underlying pathology was detected. After the dose of sertraline was increased to 100 mg/day, oedema became severe. The oedema regressed after the drug was discontinued. However, when depressive symptoms recurred, sertraline was restarted at 50 mg/day and oedema reappeared. Detailed investigations revealed no other cause. Considering the temporal relationship between sertraline use and the onset of symptoms, it was considered as sertraline-induced periorbital oedema. DISCUSSION:Some psychotropic drugs, such as mianserin, fluoxetine, paroxetine, risperidone and olanzapine, have been associated with periorbital oedema. However, this side effect has rarely been reported with sertraline and the mechanism is not known. This case highlights the need to be aware of periorbital oedema as a potential side effect of sertraline use. It is recommended to consider this rare but important side effect when prescribing sertraline in clinical practice.[Informed consent has been obtained from the patient mentioned in this case report]