Turkish Journal of Psychiatry

Turkish

	Home Page
	Online Submission
	Recent Issue
	Archive
	About
	Instructions for Authors
	Articles in Press
	Editorial Board
	Contact

Inflammation and Neurodegeneration in Patients with Early-Stageand Chronic Bipolar Disorder Sercan KARABULUT, İlker TAŞDEMİR, Uğur AKCAN, Cem İsmail KÜÇÜKALİ, Erdem TÜZÜN, Sibel ÇAKIR 2019 30(2): 75-81
[Back] [Full Text (PDF)] [E-Mail to Author]

Objective: The increase in the circulatory cytokine levels observed
in patients with bipolar disorder (BD) may imply involvement of
inflammation in the pathogenesis of mood disorders. However, the
association between the inflammatory process and the stage and severity
of illness is not well understood. In this study, our aim was to investigate
the association between neuroinflammation and disease progression in
the clinical course of BD.
Method: IL-6, TNF-α, IL-1 receptor antagonist (IL-1RA), neuronspecific
enolase (NSE) and S100B were measured by ELISA in plasma
samples of patients at early-stage BD (n=30), chronic BD (n=77) and
healthy controls (n=30).
Results: Chronic BD patients showed significantly increased levels of all
measured inflammatory markers as compared to early-stage BD patients
and the healthy controls. IL-6 and IL-1RA levels correlated with NSE
and/or S100B levels and TNF-α levels correlated with Montgomery-
Asberg Depression Rating Scale scores and Clinical Global Impression
Scale scores.
Conclusion: Our results indicate that inflammation appears to be
particularly associated with IL-1RA and IL-6 activity, progressing at
later stages of BD and possibly associated with gliosis and neuronal loss.