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Effects of Nitric Oxide Synthase-1 Exon 1f-VNTR Gene Polymorphism on the Clinical Symptoms of Alcohol Dependence,Impulsivity and Comorbid Attention Deficit Hyperactivity Disorder

İbrahim KARAKAYA, Şeref Can GÜREL, Yavuz AYHAN, Mehmet Ali KAŞİFOĞLU, Sevilay KARAHAN, Melih Önder BABAOĞLU, Erol GÖKA, Hilmiye Nesrin DİLBAZ, Berna Diclenur ULUĞ, Başaran DEMİR
2019 30(2): 82-89
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Objective: We planned to compare individuals with alcohol dependence
(AD) and healthy controls on the frequency of NOS1 exon 1f-VNTR
gene polymorphism and to investigate the effects of this polymorphism
on the clinical symptoms of alcohol dependence, impulsiveness and
comorbid attention deficit hyperactivity disorder (ADHD) symptoms.
Method: A total of 282 participants consisting of 153 patients and 129
age and gender matched healthy individuals were inluded in the study.
All participants were evaluated with Structured Clinical Interview for
DSM-IV Axis 1 disorders (SCID-I) and Michigan Alcohol Screening
Test (MAST), Barratt Impulsiveness Scale (BIS-11), UPPS Impulsive
Behavior Scale, Adult Attention Deficit and Hyperactivity Diagnosis
Scale (ADHDS), Family History Research Diagnostic Criteria
(FHDRC). The QF-PCR fragment protocols were used for genetic
analyses. Allele fragments of ≤176 bp and >176 bp sizes were
separated and 3 different genotypes were determined as the SS, SL and
LL. Associations of these genotypes with symptoms of AD severity,
impulsiveness and comorbid ADHD were investigated.
Results: The AD and control groups did not differ significantly on the
basis of NOS1 exon 1f-VNTR gene polymorphism. Also, significant
correlations between this polymorphism and symptoms of AD severity,
impulsiveness and ADHD were not determined.
Conclusion: Results of our study do not indicatea significant association
between the NOS1 exon 1f-VNTR genotypes and AD, subgroups of
AD, impulsiveness or comorbid ADHD semptoms.