Turkish
 
Home Page
Online Submission
Recent Issue
Archive
About
Instructions for Authors
Articles in Press
Editorial Board
Contact
  

Keyword

Title

Summary



   
The Association between the Extended Psychosis Phenotype and COMT val158met and BDNF val66met polymorphisms

Tolga BİNBAY, Umut KIRLI , Emre MISIR, Hayriye ELBİ, Bülent KAYAHAN, Hüseyin ONAY, Ferda ÖZKINAY, Marjan DRUKKER, Jim van OS, Köksal ALPTEKİN
2018 29(4): 221-228
[Back]    [Full Text (PDF)]    [E-Mail to Author]
Objective: Psychotic disorders were previously associated with catechol-
O-methyltransferase (COMT) val158met (rs4680) and brain-derived
neurotrophic factor (BDNF) val66met (rs6265) polymorphisms.
This article evaluates the association between COMT/BDNF
polymorphisms and the extended psychosis phenotype which covers
not only schizophrenia but also subclinical expressions of psychotic
experiences.
Method: The participants of this study were part of the TürkSch (Izmir
Mental Health Survey for Gene-Environment Interaction in Psychoses),
a longitudinal study Psychotic experiences and disorders were screened
437. The extended psychosis phenotype was grouped into four: (1) no
psychotic experiences (n: 194), (2) subclinical psychotic experiences
(n: 87), (3) clinically relevant psychotic experiences (n: 104), and (4)
schizophrenia-like disorders (n: 52). BDNF rs6265 was genotyped
occurred in every participant whereas COMT rs4680 genotyping could
be done on 366 individuals.
Results: There was no association between the extended psychosis
phenotype and BDNF rs6265/COMT rs4680 polymorphisms. The
frequency of met carriers in the BDNF rs6265genotype was slightly
higher in individuals with subclinical psychotic experiences than in
the group with no psychotic experiences, which was just below the
significance level (p=0.08).
Conclusion: The lack of an association between different expression
levels of the extended psychosis phenotype and the BDNF rs6265/
COMT rs4680 polymorphism might be related to sample characteristics,
underlying gene-gene, gene-environment and gene-environment-gene
interactions.