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Relationship Between Alcohol Dependence and Neuropeptide Y (NPY) Gene Promoter Polymorphisms in A Turkish Sample

Hayriye AKEL BİLGİÇ, Şeref Can GÜREL, Yavuz AYHAN, Sevilay KARAHAN, İbrahim KARAKAYA, Melih BABAOĞLU, Nesrin DİLBAZ, Berna Diclenur ULUĞ, Başaran DEMİR, Çağatay KARAASLAN
2020 31(4): 232-238
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Objective: Neuropeptide Y (NPY) is a protein widely expressed in the
central nervous system and involved in diverse physiological processes,
such as emotional regulation, nutritional behavior, and stress. In some
populations, studies on alcohol dependence (AD) and the NPY gene
have found that NPY variations increase alcohol consumption and thus
may potentially be associated with AD. In this study, we investigated
the relationship between NPY gene promoter polymorphisms and
phenotypes related to alcohol use.
Method: A total of 417 male participants comprising 252 individuals
with AD and 165 healthy individuals were included in this study and
phenotypic data were collected. Polymerase chain reaction-restriction
fragment length polymorphism (PCR/RFLP) and DNA sequencing
methods were used for genotyping the rs16147 and rs17149106
polymorphisms in the promoter region of the NPY gene. The data of
384 participants were analysed to evaluate the possible relationship
between genotypes and the diagnosis of AD, family history of AD, the
severity of AD using the Michigan Alcoholism Screening Test (MAST),
the age of onset of problematic alcohol use, the average amount of
alcohol consumed per day for the last six months and the lifetime
maximum alcohol consumption in one day.
Results: A significant difference was found between the AD and control
groups concerning rs16147 polymorphism genotype distribution
(p=0.025). No association with polymorphisms and alcohol-related
phenotypes were demonstrated in the AD group.
Conclusion: To our knowledge, this study shows for the first time in
the literature that alcohol dependence is associated with NPY rs16147
polymorphism in the Turkish population.