27th National Clinical Education Symposium Presentation Abstracts

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30 APRIL 2025, WEDNESDAY
09.00-10.15 ORAL PRESENTATION SESSION - 10

Evaluation of the Relationship Between Neutrophil/Lymphocyte, Platelet/Lymphocyte and Monocyte/Lymphocyte Ratios and the Type of Mood Disorder in Patients Presenting to the Psychiatry Outpatient Clinic During a Depressive Episode

Hacer Reyyan Demirel1, Şeyda Nur İspir Çaltıner1, Fatih Ekici1

1. Selçuk University Faculty of Medicine Hospital, Department of Psychiatry

DOI: 10.5080/kes27.abs86 Page 110

BACKGROUND AND AIM:.Interest in the role of the inflammatory response in mood disorders is increasing. Considering that depressed patients with BD show higher subclinical inflammation than MDD patients, the use of inflammatory parameters in differential diagnosis becomes importance.The aim of this study was to evaluate the relationship between Neutrophil/Lymphocyte,Platelet/Lymphocyte and Monocyte/Lymphocyte ratios measured during the depressive period in patients with unipolar depression and mania/hypomania that may develop during the follow-up period.
METHODS:The data of individuals over the age of 18 diagnosed with depressive disorders and followed up at the Psychiatry Outpatient Clinic of Selçuk University Faculty of Medicine Hospital between 01/01/2019 and 01/01/2025 were retrospectively analyzed.NLR, PLR and MLR were calculated retrospectively from complete blood count tests. Ethics committee approval was obtained (2025/138).
RESULTS:Our sample of 40 people consisted of 62.5% women, with a mean age of 46.3 ± 16.1 years and a mean age of depression onset of 35.2 ± 13.7 years.The mean HDRS-17 during the first depressive episode was 21.0 ± 6.2.The average follow-up duration was 4.4 ± 3.1 years.During follow-up 17.5% of the patients experienced a manic/hypomanic episode.There was no significant relationship between the presence of a manic episode during follow-up and the inflammatory markers measured during the first depressive episode including NLR1(p=0.33), PLR1(p=0.84), MLR1(p=0.86), SII(platelet × neutrophil/lymphocyte)(p=0.63) and SIRI (neutrophil × monocyte/lymphocyte)(p=0.88). When the ratios of inflammatory blood parameters between the last depressive/manic episode and the first episode were examined, no significant relationship was found between NLR2/1(p=0.10), PLR2/1 (p=0.52), MLR2/1(p=0.19) and SIRI2/1(p=0.49) and diagnostic conversion.However a significant relationship was observed with SII2/1(p=0.045).
CONCLUSIONS:Although we are still far from identifying a molecular biomarker to distinguish unipolar and bipolar depression, the rate of change in inflammatory blood parameters may provide insights into the position of the disease within the mood disorder spectrum. Beyond this study larger and longitudinal studies are needed.