27th National Clinical Education Symposium Presentation Abstracts

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28 APRIL 2025, MONDAY
10:15 - 11:30 ORAL PRESENTATION SESSION - 1

Effectiveness Of Transcranial Magnetic Stimulation Treatment In Unipolar And Bipolar Depression

Meryem Betül Aydın Akça1, Bengü Yücens1, Selim Tümkaya1

1. Department of Psychiatry, Pamukkale University, Denizli, Turkey

DOI: 10.5080/kes27.abs2 Page 22

BACKGROUND AND AIM:Transcranial Magnetic Stimulation (TMS) is a non-invasive neuromodulation technique that stimulates neural circuits in the brain without requiring anesthesia. Standard TMS with round and figure-of-eight (Fo8) coils has been shown to be effective in treating depression when applied to the dorsolateral prefrontal cortex (DLPFC). This study aims to evaluate the effectiveness of TMS in patients with unipolar and bipolar depression treated in our clinic.
METHODS (Ethics Committee Approval must be obtained and the number should be specified.):Retrospective analysis was conducted on sociodemographic data forms, Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) scores collected before and after treatment from patients receiving TMS in our clinic. Data from 23 unipolar and 8 bipolar depression patients who completed the forms were included. TMS was applied to the DLPFC using an Fo8 coil. Wilcoxon Signed-Rank Test was used to assess treatment response. Ethical approval was obtained on 26/11/2024 (decision number: 615535).
RESULTS:Among unipolar depression patients, 15 (65.2%) were female, and 8 (34.8%) were male, with a mean age of 47.56±17.57. TMS was applied at 10 hertz for 21 patients and 50 hertz for 2 patients, with a mean of 21.56±6.37 sessions. Pre-treatment BDI and BAI scores were 34.41±10.75 and 20.77±15.15; post-treatment scores were 25.13±12.2 and 16.68±13.42, respectively. Among bipolar depression patients, 4 (50%) were female, and 4 (50%) were male, with a mean age of 42.62±16. All received 10 hertz TMS with a mean of 19.75±0.7 sessions. Pre-treatment BDI and BAI scores were 31.13±13.06 and 9.57±7.02; post-treatment scores were 18.69±1.01 and 8.7±6.27, respectively. BDI scores significantly decreased in unipolar depression patients (p<0.001), while the reduction in bipolar depression patients was at the significance threshold (p=0.05). No significant decrease was observed in BAI scores for either group.
CONCLUSIONS:TMS significantly reduced depressive symptoms in unipolar depression patients, while its effectiveness in bipolar depression patients was at the threshold of significance.