Quetiapine is an atypical antipsychoticapproved by the FDA (Food and Drug Administration) for use in the treatment ofschizophrenia, acute mania, and bipolar depression. Pharmacologically, it hasantagonistic effects on serotonin 5-HT1A and 5-HT2A, dopamine D1 and D2,histamine H1, and adrenergic α1 and α2 receptors. In addition toreports of its use in schizophrenia and bipolar disorder, many studies haveexamined the use of quetiapine in the treatment of anxiety disorders andsubstance use disorders. In the treatment of patients with psychotic or bipolardisorder with a comorbid substance abuse disorder even though quetiapine wasprescribed primarily for the treatment of the underlying psychotic symptoms,patients taking this medication reported a significant reduction in substanceuse. Yet, there are also case reports of quetiapine abuse and dependence; inparticular among prisoners and patients diagnosed with substance abuse. Thoughquetiapine should be used peroral, it is also used intranasally andintravenously in these patient groups. Moreover, in some cases quetiapine iscombined with other substances, such as cocaine or marijuana, to increasesedation. This abuse of quetiapine is thought to occur due to the anxiolytic andsedative effects of the drug. There are no controlled studies on quetiapinedependence in the literature and it remains unknown whether or not quetiapinecauses dependence. This review aimed to present all published case reports onquetiapine abuse and to discuss the possible mechanisms that underlie its abuseand dependence.