Kannabis Kullanan Olgularda Optik Koherens Tomografi Bulguları

2020; 31(4): 239-243
[PDF]    [Makaleyi Göster]    [Özet]    [Yazara Mail]
Optical Coherence Tomography Findings in Cannabis Users

Objective: In this study, we aimed to evaluate the effects of cannabis use
on the retinal nerve fiber layer (RNFL) and the macular ganglion cell
– inner plexiform layer GCL-IPL using optical coherence tomography
Method: This prospective, comparative study included 26 cannabis
users who were evaluated at the Psychiatry Outpatient Unit of Muş
State Hospital and 27 age and gender matched healthy controls. OCT
was performed on both groups. The RNFL and GCL - IPL thicknesses,
measured automatically by OCT, were recorded and compared between
the groups.
Results: The sociodemographic parameters of the two groups did
not differ. The mean retinal nerve fiber thickness and thickness at the
superior, nasal, inferior quadrants were not significantly different; but
there was a significant difference at the temporal quadrant (p=0,022).
In the analysis of macular ganglion cell – inner plexiform layer, the
mean values as well as the infetotemporal, inferior, inferonasal and
superonasal quadrants did not show significant differences. But there
was a statistically significant decrease in the superior and superotemporal
quadrants (p=0,006, p=0,027).
Conclusion: These findings suggest that cannabis use leads to the
thinning on retinal layers. As it is an easily observable part of the brain,
evaluating retinal nerve fiber and ganglion cell layer with OCT may
be important for monitoring toxic and degenerative effects in cannabis
Key Words: Optical coherence, cannabis, retinal nerve fiber