Bipolar Bozukluk Tanılı Hastalarda 10 Yıllık Kardiyovasküler Hastalık Riski

2020; 31(4): 225-231
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Ten-Year Risk of Cardiovascular Disease in Patients with Bipolar Disorder

Objective: Patients with bipolar disorder (BPD) are less likely to
seek treatment for cardiovascular diseases (CVD) despite the two
fold increased CVD-related death rate in BPD. The aim of this study
was to evaluate the relationship between clinical variables, exercise
characteristics and 10-year risk of CVD in patients with bipolar I
disorder (BPD-I).
Method: The study was carried out with 106 euthymic BPD-I patients
who were followed up at the Mood Disorders Centers of Bakırköy
Hospital for Mental and Neurological Diseases and Selcuk University
Faculty of Medicine. The physical activity status of the patients were
evaluated with the Godin Leisure-Time Exercise Questionnaire
(GLTEQ) and the prospective 10-year risk of CVD was assessed by the
QRISK®2-2017 - CVD risk algorithm.
Results: Mean age of the patients were 39.5±8.6 years. The mean
QRISK2 score of the patients was 3.64±0.46 %, which did not differ
with respect to the gender. Patients’ mean healthy heart age (QAGE) was
8.49±6.46 years ahead of their current age. There was a weak negative
correlation between GLTEQ total score and QRISK2 score (r= 0.168),
but this was not statistically significant. However, statistically significant
positive correlations were determined between the categorical QRISK2
score and the disease age of onset (RR:1.18; 95%CI:1.09-1.28),
treatment duration (RR:1.16; 95%CI:1.05-1.29) and the inclusion
of atypical antipsychotic agents in the treatment received (RR:5.99;
Conclusion: A strong positive correlation was determined in this study
between the QRISK2 score and the use of atypical antipsychotic drugs
in the treatment of the BPD-I patients. It is important to identify
patients diagnosed with bipolar disorder with a high risk of developing
CVD to review the psychiatric treatment and to encourage the patients
for preventive approaches.
Key Words: Bipolar disorder, cardiovascular diseases, QRISK2, cardiovascular disease risk