Özgül Öğrenme Bozukluğu Olan Çocuklarda Serum Beyin Kaynaklı Nörotrofik Faktör (BKNF) Düzeyi

Gülser ŞENSES DİNÇ, Esra ÇÖP, Zeynep GÖKER, Aylin ŞAHİN, Seda BEĞLİ, Özlem HEKİM, Filiz Meryem ALTAY, Atilla ÇİFCİ, Özden ÜNERİ
2020; 31(3): 185-191
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Serum Brain-Derived Neurotrophic Factor (BDNF) Level in Children with Specific Learning Disabilities

Objective: Specific learning disorder (SLD) is a neurodevelopmental
disorder frequently seen in childhood with deficits in many areas of
functioning. Although the etiology of SLD is known to be multifactorial,
research findings are limited. In this study, we aimed to compare the
serum levels of brain-derived neurotrophic factor (BDNF) in children
with SLD to healthy children to find out whether BDNF has a role in
the pathophysiology of SLD.
Method: The study included 30 children between the ages of 7-12,
diagnosed with SLD and 30 age and gender matched healthy controls.
The groups were tested on the Affective Disorders and Schizophrenia
Interview Schedule for School-age Children–Now and Lifetime Form
(K-SADS-PL), the Wechsler Intelligence Scale for Children-revised
form (WISC-R), the Teacher Information Form (TIF) and the Specific
Learning Difficulty Battery (SLDB).
Results: No difference the serum BDNF levels in children with SLD
and the healthy controls. BDNF levels did not correlate with the
WISC-R scores and reading rate in the SLD group.
Conclusion: An association was not determined between SLD and
and serum BDNF levels. Our study was the first to investigate this
relationship and provided preliminary data on this topic. There is a need
for further studies with large patient groups of phenotypic homogeneity.
Key Words: Brain-derived neurotrophic factor, learning, child