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Klozapinin Hipokampusta Proton Manyetik Rezonans Spektroskopi Bulguları Üzerine Etkisi

Elçin ÖZÇELİK EROĞLU, Aygün ERTUĞRUL, Kader Karlı OĞUZ, Sevilay KARAHAN, M. Kâzım YAZIC
2020; 31(3): 159-167
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SUMMARY
Effect of Clozapine on Proton Magnetic Resonance Spectroscopy Findings in Hippocampus

Objective: The purpose of this study was to investigate the effect of
clozapine on proton magnetic resonance spectroscopy (1H-MRS)
findings in hippocampus in patients with schizophrenia. In addition,
the relationship between the change in 1H-MRS findings and the change
in psychopathology and neurocognitive functions was evaluated.
Method: Patients with schizophrenia (n=16) were assessed with the
Positive and Negative Syndrome Scale (PANSS), Clinical Global
Impression Scale (CGI), a neurocognitive test battery and 1H-MRS
at baseline, and twelve weeks after the initiation of clozapine. Healthy
controls (n=8) were assessed once with a neurocognitive test battery and
1H-MRS. Bilateral multivoxel and left single voxel NAA/Cr, Cho/Cr,
MI/Cr was calculated in the hippocampi.
Results: After 12 weeks of clozapine treatment, PANSS and CGI
scores decreased; immediate recall, cumulative learning subtests of the
Rey Auditory Verbal Learning Test, Category Verbal Fluency Test and
Wechsler Memory Scale’s visual reproduction delayed subtest scores
increased significantly. Compared with healthy controls and patients
after clozapine, hippocampi multivoxel and single voxel NAA/Cr, Cho/
Cr, MI/Cr ratios were not different in patients before clozapine. No
significant correlations between change in 1H-MRS metabolite ratios
and change in psychopathology, neurocognitive functions were detected.
Conclusion: This study is the first longitudinal study to investigate
the effect of clozapine in hippocampus with 1H-MRS. There were no
significant changes in 1H-MRS findings in hippocampi after twelve
weeks of clozapine treatment. Clozapine’s effect in hippocampus should
be investigated further in longer follow up studies with larger samples
to reach a final conclusion.
 
Key Words: Schizophrenia, hippocampus, clozapine, magnetic resonance spectroscopy