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Klozapin Kullanımına Bağlı Kilo Kaybı: Vaka Sunumu

Emre MUTLU, Elçin ÖZÇELİK EROĞLU, Yavuz AYHAN, A. Elif ANIL YAĞCIOĞLU, M. Kâzım YAZICI
2020; 31(2): 143-145
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SUMMARY
Weight Loss Associated with Clozapine: A Case Report

Clozapine is one of the second generation antipsychotics most
commonly associated with serious metabolic side effects including
weight gain. Unexpectedly, weight loss can also be seen as a rare side
effect of clozapine. The mechanism underlying clozapine induced
weight loss is not clearly understood. Several factors including certain
brain areas, neurotransmitters, neuropeptides and genetic variants were
identified to play a role in weight loss associated with clozapine. In some
patients who were reported to have a significant weight loss (13.5-50%
of body weight) with clozapine, weight loss might not be associated
with any underlying physical disorder. Weight loss may be due to the
patients’ engagement in diet and exercise after clinical improvement,
pharmacodynamic effects of clozapine, or other medical problems
such as gastrointestinal tract hypomotility caused by clozapine. Some
case reports suggested that clozapine-associated weight loss might be a
sign of poor response to clozapine. Clinicians should keep in mind the
fact that a specific group of patients may lose weight during clozapine
treatment. In this case report, possible causes of weight loss due to
clozapine use is discussed. We also discussed the possible relationship
between clozapine dose and weight loss which has not drawn attention
in previous case reports
 
Key Words: Schizophrenia, clozapine, weight loss, treatment resistance