English
 
   
Psikotrop İlaç Kullanımı, Başka Tıbbi Hastalığı ve Psikiyatrik Eş Tanısı Olmayan Panik Bozukluğu Hastalarında 24 Saatlik Kalp Hızı Değişkenliğinin Değerlendirilmesi

Nermin GÜNDÜZ, Esma AKPINAR ASLAN, Fatma EREN, Hatice SODAN TURAN, Mustafa ÖZTÜRK, Ümit TURAL
2019; 30(4): 236-244
[PDF]    [Makaleyi Göster]    [Özet]    [Yazara Mail]
SUMMARY
Analysis of 24-Hour Heart Rate Variability among Panic Disorder Patients without Previous Drug Treatment and Comorbid Disorders

Objective: One of the methods used to assess autonomic nervous
system dysfunction in the etiology of panic disorder (PD) is heart
rate variability (HRV). HRV is controlled by the sympathetic and
parasympathetic (vagal) branches of the autonomic nervous system and
reflects the capacity of autonomic stimulation by the parasympathetic
system. The aim of this study was to evaluate heart rate variability
(HRV) time domain parameters based on twenty four hour holter ECG
analysis among drug-naive patients with panic disorder (PD) without
any other medical and psychiatric comorbidity.
Method: The study group consisted of 41 patients with PD and
46 healthy controls. Participants were evaluated with SCID-1 for
psychiatric diagnoses. Then Hamilton Depression Rating Scale
(HDRS), Hamilton Anxiety Rating Scale (HARS), Panic Disorder
Severity Scale (PDSS) and Clinical Global Impression Scale (CGI-S)
were applied to participants. Twenty four hour Holter ECG outcomes
were analyzed on a computer program and time domain parameters
were evaluated.
Results: Among the parameters analyzed from HRV, SDANN was
significantly higher (p <0.001); duration of RMSSD, NN50 and
pNN50 were lower in PD group than the control group (p = 0.003, p
= 0.005, p = 0.047, respectively). In the correlation analysis, there was a
moderate negative correlation between CGI-S and NN50 and pNN50.
In logistic regression analysis, the increase in SDNN was found to
increase the probability of PD by 1.11 (95% CI, 1.010-1.209); the
increase in SDANN was found to decrease the probability of PD by
0.892 (95% CI, 0.818-0.973), and the increase in pNN50 was found to
decrease the probability of PD by 0.523 (95% CI, 0.342-0.801).
Conclusion: The data obtained in our study confirm that there is a
decrease in some HRV parameters like RMSSD, NN50 and pNN50
reflecting parasympathetic activity among patients with PD.
Key Words: Panic disorder, heart rate variability, autonomic nervous system, spectral analysis