Lityumun Kalsiyum ve Parathormon Düzeyi Üzerine Etkisi: Sağlıklı Kontrollerle Karşılaştırmalı Kesitsel Bir Çalışma

2019; 30(3): 163-171
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The Effects of Lithium on Calcium and Parathormone Levels: A Cross-sectional Study with Healthy Controls

Objective: Despite lithium associated hyperparathyroidism (LAH) can
lead to many complications, little notice has been paid to this sideeffect. The aim of this study was to investigate the effects of lithium
on calcium and parathyroid hormone levels and the relation between
lithium use and thyroid diseases.
Method: This cross-sectional study was carried out with 87 lithiumtreated patients and 65 volunteers who had a similar age and gender
distribution with the lithium group. Serum levels of corrected calcium,
intact parathormone, phosphorus, magnesium, alkaline phosphatase,
free thyroxine, thyroid stimulating hormone, thyroid autoantibodies
and creatinine were assessed, and also, thyroid and parathyroid
ultrasonography was conducted. Further detailed investigations were
made depending on the elevation of the initially measured calcium and/
or parathormone levels.
Results: Median values of serum levels of the corrected calcium and
the intact parathormone were significantly higher in the lithium group.
Calcium levels had a mild correlation with the duration of lithium
treatment. In the first assessment, while all control individuals had
values within the normal reference range, 11 lithium-treated patients had
corrected calcium and/or intact parathormone levels above the normal
reference levels. All of the five patients, who were diagnosed with LAH
after further investigation, were also diagnosed with a thyroid disorder.
Conclusion: These results demonstrate that lithium treatment has a
relationship with calcium and parathormone levels. The 5.7% prevalence
of LAH and potential life-threatening conditions associated with LAH
necessitates the use of available low-cost methods to monitor blood
calcium levels of lithium-treated patients for early diagnosis.
Key Words: Calcium, hyperparathyroidism, lithium, parathormone, parathyroid glands